Research and Evidence-Based Practice

OR, RRR, NNT and other measures of efficacy

OR, RRR, NNT and other measures of efficacy

Trials which stop earlier than expected - why would they do that?

Quality of a systematic review: what to look for

Platform trials - definition, advantages, disadvantages

Randomisation- simple, block, stratified and covariate adaptive

Platform trials: design, advantages and disadvantages

Terminology in statistics, including the ROC curve

Non-inferiority trials

Statistics definitions: external validity, concealment, stratification, etc

Terminology in statistics: odds ratio, CI and P value

Terminology in statistics: odds ratio, CI and P value

Terminology in statistics: odds ratio, CI and P value

Clinical trial methodology: a list of memorised definitions

Cluster randomisation and non-inferiority trials

Elements of randomisation

Non-inferiority trials

Critical appraisal of randomised controlled trials

Definitions of terms in statistics: prevalence, relative risk and attributable risk

Calculate sensitivity, specificity, PPV, NPV and accuracy

Allocation concealment , block randomisation, stratification, minimisation algorithm.

Anatomy of the forest plot; advantages and disadvantages of meta-analysis

 Meta-analysis: advantages and disadvantages. Also, the funnel plot

Define: external validity, bias and selection bias. 

 Meta-analysis: advantages and disadvantages. Also,  publication bias.

Analysis of clinical trials: overall assessment of quality

Define "EBM"; also, levels of evidence and intention to treat analysis

Definitions: Risk ratio, NNT, P-value and confidence interval.

Blinding and allocation concealment

Definitions Relative risk, absolute risk, NNT, and the power of a study.

Calculate: Relative risk, absolute risk, NNT

Calculate sensitivity, specificity, PPV and NPV

The receiver operating characteristic plot, i.e. ROC curve.

 Meta-analysis:  the forest plot. Its anatomy in some detail.

Definitions: Type 1 error, type 2 error, study power, sample size and effect size.

Calculate sensitivity, specificity, PPV and NPV.

Definitions: Phase III trial, absolute and relative risk reduction, NNT.

 Meta-analysis:  features suggestive of "high quality".

Definitions: sensitivity, specificity, PPV NPV and the positive likelihood ratio.

Define intention to treat analysis and randomisation.

Definitions: relative risk, absolute risk, NNT and study power.

The Kehoe principle and the Precautionary principle

Definitions: sensitivity, specificity, PPV and NPV.

Parametric and non-parametric analytical tests

Analysis of clinical trials: Methodological quality

Tests of statistical significance: Chi-squared test, Fisher’s Exact Test and logistic regression.

Definitions: sensitivity, specificity, PPV and NPV.

Analysis of clinical trials: criteria used to assess validity.

Explore the "relevance" of evidence based medicine in ICU