Define cerebral perfusion pressure (CPP). List the advantages and limitations of using
CPP as a therapeutic target in the management of traumatic brain injury
Definition : CPP = MAP-ICP Advantages: Easily monitored
Can be monitored continuously
Nursing staff familiar
BTF guidelines endorse use of CPP at 60
Limitations: Used as a surrogate for CBF
CVR is variable and therefore changes in CBF not detected by CPP
Does not allow for differential autoregulation in the normal and injured brain. Therapy to maintain CPP can result in lung injury
No Class I data to support use
Poor correlation between CPP and indices of brain oxygenation
This question closely resembles Question 1 from the second paper of 2009.