A 58 year old male is admitted with haematemesis. His coagulation profile is shown below. List 2 likely causes of his coagulation abnormalities?
|
Test |
Value |
Normal range |
|
PT |
*25.9 sec |
(12-14) |
|
APTT |
*39 sec |
(34-38) |
|
INR |
*2.4 |
(0.8-1.2) |
1) Liver dysfunction due to alcoholic or viral liver disease.
2) Vit K deficiency
3) Patient on warfarin therapy.
The question really asks, "What differen reasons could here be for an isolated PT elevation".
In a guy who is vomiting blood, alcoholism and liver disease are high up on the list.
An isolated PT elevation could be caused by:
The whole spectrum of abnormal coagulation studies is discussed in greater detail elsewhere.
Prothrombin Time, from the wonderful Practical-Haemostasis.com
Mariani, Guglielmo, and Francesco Bernardi. "Factor VII deficiency." Seminars in thrombosis and hemostasis. Vol. 35. No. 4. 2009.