Question 6.3

A 58 year old male is admitted with haematemesis. His coagulation profile is shown below. List 2 likely causes of his coagulation abnormalities?



Normal range


*25.9 sec



*39 sec





[Click here to toggle visibility of the answers]

College Answer

1) Liver dysfunction due to alcoholic or viral liver disease.
2) Vit K deficiency
3) Patient on warfarin therapy.


The question really asks, "What differen reasons could here be for an isolated PT elevation".

In a guy who is vomiting blood, alcoholism and liver disease are high up on the list.

An isolated PT elevation could be caused by:

  • Vitamin K deficiency
    • Malabsorption (leading to vitamin K deficiency)
  • Vitamin K antagonists e.g. warfarin, phenindione, rodenticides
  • Liver disease
  • Isolated Factor VII deficiency

The whole spectrum of abnormal coagulation studies is discussed in greater detail elsewhere.


Prothrombin Time, from the wonderful

Mariani, Guglielmo, and Francesco Bernardi. "Factor VII deficiency." Seminars in thrombosis and hemostasis. Vol. 35. No. 4. 2009.