A colleague directs your attention to a recently published randomised trial on a therapeutic intervention.
Outline the features of the trial that you would lead you to change your practice.
Points to consider in the answer would be:
This question really asks, "how do you assess an RCT for validity?"
This is addressed in greater detail elsewhere.
Oh's Intensive Care manual: Chapter 10 (p83), Clinical trials in critical care by Simon Finfer and Anthony Delaney.
CASP (Critical Appraisal Skils Program) has checklists for the appraisal of many different sorts of studies; these actually come with tickboxes. One imagines reviewers wandering around a trial headquarters, ticking these boxes on their little clipboards.
CEBM (Centre for Evidence Based Medicine) also has checklists, which (in my opinion) are more informative.
Here is a link to their checklist for the critical appraisal of an RCT.