A colleague directs your attention to a recently published randomised trial on a therapeutic intervention.
Outline the features of the trial that you would lead you to change your practice.
Points to consider in the answer would be:
This question really asks, "how do you assess an RCT for validity?"
This is addressed in greater detail elsewhere.
In brief:
Oh's Intensive Care manual: Chapter 10 (p83), Clinical trials in critical care by Simon Finfer and Anthony Delaney.
The JAMA collection via the John Hopkins Medical School
CASP (Critical Appraisal Skils Program) has checklists for the appraisal of many different sorts of studies; these actually come with tickboxes. One imagines reviewers wandering around a trial headquarters, ticking these boxes on their little clipboards.
CEBM (Centre for Evidence Based Medicine) also has checklists, which (in my opinion) are more informative.
Here is a link to their checklist for the critical appraisal of an RCT.