a) List four predisposing conditions and four precipitating factors which may lead to the occurrence of dynamic left ventricular outflow tract obstruction in critically ill patients.
b) What specific cardiovascular clinical signs on physical examination may be present in a patient with left ventricular dynamic outflow obstruction? (20%marks)
c) What are the principles of medical treatment in a patient with shock secondary to dynamic outflow obstruction? (40% marks)
a) Predisposing conditions
Left ventricular hypertrophy (e.g. Hx of hypertension or aortic stenosis)
Post AVR or TAVI for aortic stenosis
Vasodilatation e.g. anaesthesia, sepsis, nitrates, liver failure
b) Ejection systolic murmur lower left sternal edge which may vary in intensity over time as the gradient changes
An associated MR murmur is common
Signs of low CO syndrome i.e. hypotension, oliguria, lactic acidosis, end organ hypoperfusion
c) Fluid loading
Vasocontrictors (preferably without b effect i.e. phenylephrine / vasopressin) increase afterload without increasing heart rate
Negative inotrope / chronotrope e.g. b blockade
–control heart rate
Treat underlying conditions
This was generally answered well. Candidates who did poorly didn't know how to manage patients with outflow tract obstruction and recommended dangerous therapies including inotropic therapy and vasodilator agents.
Given that this was "generally answered well", one might assume that a detailed breakdown of the subject is probably superfluous and that only cosmetic changes could be made to enhance the already excellent college answer. That is reasonably accurate. Unfortunately, the same cannot be said for the question. Specifically, the distinction between "predisposing conditions" and "precipitating factors" is difficult to parse. Is a mitral valve replacement a "condition" or a "factor"? If it's a predisposing condition, then why isn't liver failure a predisposing condition? Confusion prevails. In order to make sense of this, "predisposing conditions" here are interpreted as "structural factors" and precipitating factors are interpreted as "functional factors".
Clinical features include:
Management consists of targeting the following parameters:
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