A 25-year-old male is admitted to the Emergency Department with fatigue, fevers and hypotension. He is now stable, requiring moderate dose vasopressor support, and has been transferred to the ICU for ongoing management.
Blood cultures taken on admission have grown Staphylococcus aureus, resistant to penicillin but sensitive to methicillin.
Outline your assessment and specific management related to the staphylococcal bacteraemia.
More explanation for the specific choice of investigations and antibiotics is available in the staphylococcal bacteremia chapter. Unfortunately, all efforts to produce a concise answer (one which could be written in the space of ten minutes) have failed, yielding to the irresistible completionist urge, and producing a "model answer" that is comprehensive and impossible.
Foster, Timothy. "Staphylococcus." (1996).
Thwaites, Guy E., et al. "Clinical management of Staphylococcus aureus bacteraemia." The Lancet infectious diseases 11.3 (2011): 208-222.
DeLeo, Frank R., Binh An Diep, and Michael Otto. "Host defense and pathogenesis in Staphylococcus aureus infections." Infectious disease clinics of North America 23.1 (2009): 17-34.
Sakwinska, Olga, et al. "Staphylococcus aureus host range and human-bovine host shift." Applied and environmental microbiology 77.17 (2011): 5908-5915.
Williams, R. E. O. "Healthy carriage of Staphylococcus aureus: its prevalence and importance." Bacteriological reviews 27.1 (1963): 56-71.
Hall, Keri K., and Jason A. Lyman. "Updated review of blood culture contamination." Clinical microbiology reviews 19.4 (2006): 788-802.
Chong, Yong Pil, et al. "Persistent Staphylococcus aureus bacteremia: a prospective analysis of risk factors, outcomes, and microbiologic and genotypic characteristics of isolates." Medicine 92.2 (2013): 98.
Fowler, Vance G., et al. "Clinical identifiers of complicated Staphylococcus aureus bacteremia." Archives of internal medicine 163.17 (2003): 2066-2072.
Tong, Steven YC, et al. "Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management." Clinical microbiology reviews 28.3 (2015): 603-661.
Forsblom, E., et al. "Telephone consultation cannot replace bedside infectious disease consultation in the management of Staphylococcus aureus bacteremia." Clinical infectious diseases 56.4 (2013): 527-535.
Stewart, James D., and Naomi Runnegar. "Early use of peripherally inserted central catheters is safe in Staphylococcus aureus bacteraemia." Internal medicine journal 48.1 (2018): 44-49.