a) Discuss the use of platform trials as a research tool. Include in your answer, trial design, advantages and disadvantages. (90% marks)
b) List two examples of platform trials. (10% marks)
b) Examples from ICU literature are far fewer than the examples from oncology, where these trials are really popular. It is almost certain that most trainees would have put REMAP-CAP down for one of these, but there are a couple of others as well:
"Adaptive platform trials: definition, design, conduct and reporting considerations." Nature Reviews Drug Discovery 18, no. 10 (2019): 797-807.
Park, Jay JH, et al. "An overview of platform trials with a checklist for clinical readers." Journal of Clinical Epidemiology 125 (2020): 1-8.
Berry, Scott M., Jason T. Connor, and Roger J. Lewis. "The platform trial: an efficient strategy for evaluating multiple treatments." Jama 313.16 (2015): 1619-1620.
Antonijevic, Zoran, and Robert A. Beckman, eds. Platform trial designs in drug development: umbrella trials and basket trials. CRC Press, 2018.
Pallmann, Philip, et al. "Adaptive designs in clinical trials: why use them, and how to run and report them." BMC medicine 16.1 (2018): 1-15.
Mahajan, Rajiv, and Kapil Gupta. "Adaptive design clinical trials: Methodology, challenges and prospect." Indian journal of pharmacology 42.4 (2010): 201.
Sampson, Allan R., and Michael W. Sill. "Drop‐the‐losers design: normal case." Biometrical Journal: Journal of Mathematical Methods in Biosciences 47.3 (2005): 257-268.
Lee, Kim May, et al. "Statistical consideration when adding new arms to ongoing clinical trials: the potentials and the caveats." Trials 22.1 (2021): 1-10.