Question 1

A 60-year-old patient remains intubated with a reduced consciousness level 6 hours following endovascular clot retrieval (ECR) for an acute middle cerebral artery (MCA) stroke. Sedation was stopped immediately post procedure.

a. List six likely causes of the reduced conscious state (3 marks) b. Outline your assessment of this patient’s reduced conscious level (7 marks)

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Discussion

Syllabus topic/section: 2.1.8 Neurological Intensive Care

This question was answered well by most candidates and was assessed to be an easy question to pass. Better marks were scored by candidates who described an assessment that was tailored to the clinical scenario, rather than a more generic description of how to assess someone with a decreased conscious state.

For instance, the above standard answer would include both stroke AND procedure related history with relevant details for investigations and examination.

Interpretation

a)

  • Haemorrhagic transformation of the ifarct
  • Cerebral oedema, malignant MCA, midline shift, herniation
  • Reocclusion or initial incomplete revascularisation (eg. mTICI 1 or 2a)
  • Cerebral artery dissection
  • Seizures
  • Vascular access site complications

b) 

  • History
    • Duration from stroke onset to reperfusion
    • Initial NIHSS score and GCS at presentation
    • Aphasia pre-procedure
    • Volume of the stroke on pre-procedure imaging (predictive of malignant MCA syndrome)
    • History of sedation, anticoagulation, antiplatelet drugs, prehospital thrombolysis
    • Procedural complexity
  • Examination
    • Reassessment of the GCSm serially
    • Cranial nerve exam looking for features of herniation
    • Motor examination looking for worsening of the pre-stroke power and tone
    • Features of nonconvulsive seizures (dilated pupils, increased tone globally, clonus, hippus)
    • Carotid auscultation (bruitt of dissection?)
  • Investigations
    • ​​​​​​​Neuroimaging: CT brain noncontrast, followed by a perfusion study, and then MRI if these do not reveal the cause
    • Laboratory tests for distat possibilities such as coagulopathy, hyponatremia or hypernatremia, hypoglycaemia, and other metabolic causes of coma
    • ECG to appreciate whether the patient remains in AF and could be at further risk of emboli
    • TOE to determine whether intracardiac emboli are to be expected going forward

References

Leslie-Mazwi, Thabele, et al. "Post-thrombectomy management of the ELVO patient: Guidelines from the Society of NeuroInterventional Surgery." Journal of neurointerventional surgery 9.12 (2017): 1258-1266.

van de Graaf, Rob A., et al. "Periprocedural antithrombotic treatment during acute mechanical thrombectomy for ischemic stroke: a systematic review." Frontiers in neurology 9 (2018): 238.

Torbey, Michel T., et al. "Evidence-based guidelines for the management of large hemispheric infarction." Neurocritical care 22.1 (2015): 146-164.

Jung, Simon, et al. "Adverse Effect of Early Epileptic Seizures in Patients Receiving Endovascular Therapy for Acute Stroke." Stroke 43.6 (2012): 1584-1590.

Prabhakaran, Shyam, et al. "2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association." Stroke 57 (2026).

Li, Xiangyu, et al. "The predictors and prognosis for unexpected reocclusion after mechanical thrombectomy: a meta-analysis." Annals of Translational Medicine 8.23 (2020): 1566.

Caldwell, Stephanie, et al. "Bridging the Distance for Ischaemic Stroke Treatment in Regional Australia: A Retrospective Cohort Study." Australian Journal of Rural Health 34.2 (2026): e70177.

Zaidat, Osama O., et al. "Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement." Stroke 44.9 (2013): 2650-2663.

Gurbani, Saumya S., et al. "Post-Stroke Thrombectomy Evaluation: Expected Findings and Unexpected Complications." RadioGraphics 46.1 (2025): e250045.

Shahid, Adnan H., et al. "Risk Factors of Futile Recanalization Following Endovascular Treatment in Patients With Large-Vessel Occlusion: Systematic Review and Meta-Analysis." Stroke: Vascular and Interventional Neurology 2.6 (2022): e000257.

Wang, Jeffrey Z., et al. "Incidence and management of seizures after ischemic stroke: systematic review and meta-analysis." Neurology 89.12 (2017): 1220-1228.

Shapiro, S. Z., et al. "Access-site complications in mechanical thrombectomy for acute ischemic stroke: a review of prospective trials." American Journal of Neuroradiology 41.3 (2020): 477-481.

Prabhakaran, Shyam, et al. "2026 Guideline for the early management of patients with acute ischemic stroke: a guideline from the American Heart Association/American Stroke Association." Stroke (2026).