Non-canonical vivas for practice

Pharmaceutics, drug labelling and packaging

Pharmaceutical formulation and excipients

Enantiomerism

Single and multiple compartment models of drug distribution

Routes of administration; bioavailability and bioequivalence

Drug absorption; transfer of drugs across membranes; lipid solubility of drugs

Gastrointestinal drug absorption, the effect of gastric motility and gut flora

Volume of distribution

Clearance - renal clearance and hepatic clearance

Biotransformation, Phase I and Phase II reactions, elimination kinetics

Half-life,  context sensitive half time and effect site equilibration

Maintenance dose, loading dose and plasma drug concentration measurements

Pharmacokinetics of drugs in the epidural and subarachnoid space

Pharmacokinetics in critical illness, obesity and old age

Pharmacokinetic drug-drug interactions

Graded, quantal and ordered drug responses

Receptor theory of drug action

Structural relationships for receptors and ligands

Regulation of drug receptor number and activity

Second messenger systems

Law of mass action in pharmacodynamics 

Affinity, association constant and dissociation constant

Respiratory compliance and the factors which influence it

Resistance of the respiratory system and factors which affect airway resistance

Clinical significance and measurement of closing capacity

Functional residual capacity (FRC) and the measurement of FRC

Anatomy and physiology of pulmonary blood vessels

Physiological factors and drugs affecting pulmonary vascular resistance

Differences between the pulmonary and systemic circulations

Global and regional ventilation and perfusion

West's zones of the lung

V/Q matching and its effects on gas exchange

Dead space, its components, its measurement and physiological consequences

Venous admixture, shunt, their measurement and physiological consequences

Cardiac reflexes; specifically the baroreceptor reflex

Autoregulation within peripheral circulations

Cerebral blood flow autoregulation

Hepatic blood flow

Coronary blood flow

Renal blood flow

Splanchnic blood flow

Regional skeletal muscle blood flow

Uteroplacental blood flow

Portal systems in the regional circulation

Humoral regulation of blood volume and flow

Classification of antihypertensives, beta blockers and sympatholytic agents.

Pharmacology of furosemide

Anatomy of the sympathetic and parasympathetic nervous system

Synthesis, metabolism and receptor effects of catecholamines

synthesis, metabolism, neurotransmission and receptor effects of acetylcholine.

Composition, volumes and regulation of oral and gastric secretions

Constituents and functions of plasma; FFP cryoprecipitate and prothrombinex