Compare and contrast the pharmacology of noradrenaline and vasopressin

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College Answer

This was best answered using a table.

The main points expected for a pass were

  • Both are naturally occurring substances
  • Direct acting via receptors
  • Mechanisms by which both increase mean arterial pressure
  •  Metabolism
  • Uses in Intensive Care, septic shock, vasodilatory shock and diabetes insipidus.  
  • Side effects related to intense vasoconstriction and for vasopressin possible coronary ischaemia and sodium and water retention