Question 7

Compare and contrast the pharmacology of noradrenaline and vasopressin

College Answer

This was best answered using a table.

The main points expected for a pass were

Both are naturally occurring substances
Direct acting via receptors
Mechanisms by which both increase mean arterial pressure
Metabolism
Uses in Intensive Care, septic shock, vasodilatory shock and diabetes insipidus.
Side effects related to intense vasoconstriction and for vasopressin possible coronary ischaemia and sodium and water retention