Question 6(p.2)

Compare and contrast the pharmacology of drugs that change the pH of gastric fluid.

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College Answer

The main points candidates were expected to mention were the major drug groups (antacids,
H2 antagonists, proton pump blockers), describe their mechanism of action; briefly mention
relevant pharmacokinetics and then briefly discuss the potential problems and interactions
when using them. Additional credit was given for answers providing more detail.
Many answers did not mention antacids or prostaglandin analogues, choosing only to discuss
H2 receptor blockers and proton pump blockers. Even then, many answers included incorrect
pharmacokinetic data. Drug interactions were rarely mentioned. A discussion of normal
gastric acid secretion was not asked for and was not rewarded with marks