Outline the role of platelets in blood clotting following an injury to a blood vessel.

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College Answer

The main points expected in this answer were descriptions of platelet activation following
exposure to collagen, platelet adhesion to the endothelium and ADP release and platelet
aggregation secondary to activation of the GP11b/111a, COX-1 and other agents e.g.
prostaglandin E2
Factors that interacted with platelet receptors e.g. platelet activating factor which increase
aggregation and factors that inhibited platelet activation e.g. Prostaglandin I2 and nitric oxide
gained marks.
Syllabus J2c
Reference: Power and Kam 1st edition p 247-249