Outline the role of platelets in blood clotting following an injury to a blood vessel.
The main points expected in this answer were descriptions of platelet activation following exposure to collagen, platelet adhesion to the endothelium and ADP release and platelet aggregation secondary to activation of the GP11b/111a, COX-1 and other agents e.g. prostaglandin E2
Factors that interacted with platelet receptors e.g. platelet activating factor which increase aggregation and factors that inhibited platelet activation e.g. Prostaglandin I2 and nitric oxide gained marks.
Reference: Power and Kam 1st edition p 247-249
Role of platelets in primary haemostasis
Role of platelets in secondary haemostasis
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