Compare and contrast the pharmacology of heparin and enoxaparin.
The vast majority of candidates chose to answer this question in tabular format and in doing
so were easily able to consolidate a high scoring answer. This also allowed clear
identification of important differences, such as molecular weight, mechanism of action, halflife,
dose-interval, monitoring, elimination, reversal of effect, the influence of renal
impairment and potential side-effects.
One exception to this approach would be clinical indications, where these show marked
similarity. Candidates should consider writing similarities once whilst incorporating both
drugs so as use the time allocated more efficiently.
Syllabus - J2 2a
Reference: Pharmacology and Physiology in Anaesthetic practice, Stoelting 505-511 Basic
and Clinical Pharmacology, Katzung 546-548