Discuss the important factors in exchange of gases and substrates between capillaries and tissue cells.
Good answers were based around Fick’s Law, Starling forces and the Gibb’s
It was expected that candidates would give Fick’s equation and describe the
Fick’s Law J = -DA dc/dx
Candidates were also expected to describe Starlings equation and the equation for
Osmotic Pressure. Starling Equation:
Fluid movement = k[(Pc-Pi) – s(πp – πi)]
Osmotic pressure : sRT(Ci-Co).
Gibb’s Donnan effect and, other mechanisms of transport (filtration and pinocytosis)
was also expected for a good answer.
Syllabus: A combination C1c2.d, C21 2.e, C2b2.c, C2b2.e
References: Pharmacology and Physiology in Anesthetic Practice, Stoelting pgs
294-300, 322- 325