Outline the physiological processes that occur in a blood vessel after venipuncture (80% of marks). How are these altered by the administration of aspirin (20% of marks)?
The question was answered well overall. Better answers included detail of the
platelet receptor and mediator interactions. Discussion of the role of the platelet in
providing a phospholipid surface to enable the formation of the activated Xa complex
was expected. Modulation of the coagulation cascade and prevention of clot
propagation via protein C, nitric oxide, thrombomodulin and fibrinolysis was
important to note in a comprehensive answer. The pharmacodynamic action of
aspirin was generally understood.
Syllabus: J1,2c and J2, 2d
Recommended sources: Basic and Clinical Pharmacology, Katzung, Chp 34, 36