Question 3

Compare and contrast the pharmacology of intravenously administered atropine and glycopyrrolate

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College Answer

Most candidates exhibited a structural approach with reasonable understanding of
the pharmacology of atropine although there was a lack of precision (anticholinergic
is correct, competitive muscarinic antagonist is more precise). Some answers did not
contrast glycopyrrolate adequately. The phrase ‘hepatic metabolism, renal excretion’
needed to be accompanied with detail if marks were to be awarded.
Syllabus: G3b
Recommended sources: Goodman and Gillman, The Pharmacological Basis of
Therapeutics, Chp 7