Describe the biochemical abnormalities, and the mechanisms by which they arise, that may be observed in a patient who is taking frusemide.
This was a relatively straightforward question with marks available for listing the
abnormality and then discussing its origin. Many candidates simply listed an abnormality or
confused the direction of electrolyte change. Few candidates went beyond hypokalaemia,
hyponatraemia and hypochloraemia. Several candidates gave confused answers as to the
mechanism(s) or drew pictures of a tubule with directional arrows for electrolytes with
inadequate explanation. Some candidates simply ran out of time and wrote very little – this
is a pity as a list would have generated marks. Candidates are reminded to practise the
exams to time and attempt all questions.