Classify the anti-arrhythmic drugs using the Vaughan-Williams classification (30% of 
marks). Compare and contrast the electrophysiological effects of Class 1 anti-arrhythmic 
drugs (70% of marks).

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College Answer

Most candidates displayed a basic knowledge of the Vaughan-Williams classification and 
gave an example of each class. The remainder of the question lent itself very well to a 
tabular format. Better answers included the effect on the action potential (diagrams were 
useful here), channel dissociation kinetics (this was frequently omitted) and examples from 
each class of drug. There is an excellent table in Stoelting which answers this question 
nicely. Marks were not awarded for clinical effects.Overall, this question was generally well