Describe the pharmacology of naloxone.
Naloxone is a commonly used intravenous opioid antagonist, which acts as a competitive
antagonist with high affinity for the mu, kappa, delta and sigma opioid receptors. It is used
to ameliorate or reverse opioid effects at these sites. It has a shorter effect site and plasma
half-life than most opiates so levels will fall before the opioid agonist it is being used to
treat, thus a repeat dose maybe required to maintain opioid reversal. Overall candidates
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