Describe the pharmacology of naloxone.

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College Answer

Naloxone is a commonly used intravenous opioid antagonist, which acts as a competitive 
antagonist with high affinity for the mu, kappa, delta and sigma opioid receptors. It is used 
to ameliorate or reverse opioid effects at these sites. It has a shorter effect site and plasma 
half-life than most opiates so levels will fall before the opioid agonist it is being used to 
treat, thus a repeat dose maybe required to maintain opioid reversal. Overall candidates 
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