Describe the actions of endogenous vasopressin. (60% of marks) List the vasopressin analogues and their uses. (40% of marks)
Overall the first section was not answered in sufficient detail. Aspects such as the antidiuretic effects of vasopressin were often overlooked. Some candidates spent more time on outlining the clinical contexts in which vasopressin is used (which did not score marks), rather than the physiology (which did score marks). DDAVP was the most common analogue mentioned, with the others often being omitted (e.g. terlipressin, ornipressin, etc.).
"Describe the actions", they said. Not "spill everything you know about vasopressin the drug". Thus, the mechanisms of action of vasopressin are:
Vasopressin analogs were asked for as a list, along with their uses. Even though this was 40% of the mark, you'd not be wanting to waste any time here.
There's even more detail in the answer to Question 22 from the second Fellowship Exam paper of 2009 (in those days, pharmacology questions in the Fellowship Exam were commonplace)
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