Compare and contrast the mechanism of action, pharmacokinetics, adverse effects and monitoring of effect of dabigatran and warfarin.
Most candidates were able to provide some details about warfarin however dabigatran was
less well known. The syllabus provides a guide to depth of knowledge required for listed drugs
and so more detail was expected for Warfarin as a class “A” drug than was expected for
dabigatran (a class “C” drug). It was however expected that candidates would provide more
than just generalisations regarding “hepatic metabolism and renal excretion” when applied to
both agents that actually have different modes of elimination.