Describe the pharmacology of oxygen
Use of a general "pharmacology" structure to answer this question would help avoid significant
omissions such as only discussing pharmacokinetics or only discussing pharmacodynamics.
Oxygen has a well described list of pharmacodynamics effects that includes, cardiovascular,
respiratory and central nervous system effects. Candidates’ knowledge of the pharmaceutics was
limited for a routine drug. It was expected candidates would mention the potential for oxygen
toxicity including a possible impact on respiratory drive in selected individuals, retrolental
fibroplasia and seizures under some circumstances.
Many candidates did not answer the question asked, and instead focussed on the physiology of
oxygen delivery and binding of oxygen to haemoglobin
It is clear from the college comments that the college wanted the trainees to be able to treat oxygen as a drug in this discussion. Thus:
Physico-chemical properties of oxygen
Indications for use
O'Driscoll, B. R., et al. "BTS guideline for oxygen use in adults in healthcare and emergency settings." Thorax 72.Suppl 1 (2017): ii1-ii90.
Tibbles, Patrick M., and John S. Edelsberg. "Hyperbaric-oxygen therapy." New England Journal of Medicine 334.25 (1996): 1642-1648.
Cherniack, NEIL S., and G. S. Longobardo. "Oxygen and carbon dioxide gas stores of the body." Physiological reviews50.2 (1970): 196-243.
RAHN, HERMANN. "Oxygen stores of man." Oxygen in the Animal Organism. 1964. 609-619.
Farhi, L. E., and H. Rahn. "Gas stores of the body and the unsteady state." Journal of Applied Physiology 7.5 (1955): 472-484.
Chawla, Anuj, and A. K. Lavania. "Oxygen toxicity." Medical Journal Armed Forces India 57.2 (2001): 131-133.
Sackner, Marvin A., et al. "Pulmonary effects of oxygen breathing: a 6-hour study in normal men." Annals of internal medicine 82.1 (1975): 40-43.