Describe the pharmacology of Phenytoin (75% of marks) and Levetiracetam (25% of marks).
The knowledge of phenytoin was often superficial and many answers were too brief and didn’t
adequately cover the required material. The knowledge around levetiracetam seemed very
limited with many candidates guessing (incorrectly) what the pharmacokinetics might be. Most
answers demonstrated a structured approach to this type of question.
Better answers were able to distil major issues such as the narrow therapeutic window for
phenytoin or the potential clinical impact of differing ordered kinetics or altered metabolism.
Candidates are reminded to read each question carefully; levetiracetam should not be confused