Question 7

Outline the mechanisms that potentiate the action of non-depolarising muscle relaxants and give examples. 

[Click here to toggle visibility of the answers]

College Answer

A structured approach would work well for this question but was often lacking. Many answers 
were superficial providing short lists of factors affecting NDMRs without reference to 
mechanism. Candidates failed to differentiate factors which potentiate NDMRs from those which 
inhibit the action of the drugs. Some confusion also existed confusing speed of onset kinetics 
with potentiation kinetics. Candidates who structured their answer into pharmacokinetic and 
pharmacodynamic factors generally scored better marks. Candidates who used pre-post synaptic 
type structure tended to omit kinetics completely from their answers. Incorrect facts were