Outline the pharmacology of sodium nitroprusside (50% of marks). Discuss the mechanisms of toxicity and their management (50% of marks).
Most candidates presented a structured answer and exhibited a good understanding of the
pharmacology of sodium nitroprusside. Few candidates demonstrated an understanding of
the mechanisms of SNP toxicity and details on management of cyanide toxicity were lacking.
Cobalt EDTA is no-longer recommended as initial therapy in the management for cyanide
More specific detail was expected beyond a generic comment on "mechanisims of toxicity"
such as potentially causes of respiratory, renal, hepatic or CNS failure.
Few candidates mentioned adverse effects other than that of cyanide toxicity. Many
candidates also failed to outline the management of sodium nitroprusside toxicity