Compare and contrast the pharmacokinetics and adverse effects of morphine and fentanyl.

[Click here to toggle visibility of the answers]

College Answer

This question is best answered in a tabular form, comparing absorption, distribution, 
metabolism, excretion and the adverse effects.
Common omissions were lack of details on distribution, and not relating lipid solubility to effect. 
A description of the relative adverse effects was expected, e.g., more histamine release, less 
bradycardia, rather than listing similar adverse effects, e.g. respiratory depression.
Comparisons of pharmaceutics and pharmacodynamics did not attract any additional marks.