Discuss the determinants of intracranial pressure (80% of marks). Outline how it can 
be measured (20% of marks).

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College Answer

It was expected answers would include an explanation of the Monro-Kellie Doctrine. Many 
candidates gave insufficient details of compensatory mechanisms especially regarding 
decreased total cerebral blood volume (primarily venous) in response to increased intracranial 
Most candidates had all the information but had difficulty synthesising the information to write a 
cohesive answer. Factors affecting ICP could be divided into factors affecting CBV, factors 
affecting CSF and factors affecting brain tissue. Under factors affecting CBV the effect of blood 
gases, autoregulation, temperature, metabolism, drugs and venous obstruction could have been detailed.