Compare and contrast aspirin and clopidogrel

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College Answer

Both of these commonly used agents are level A in the syllabus and thus a high level of detail
was expected. Marks were awarded in the following areas - pharmaceutics, mechanism of
action, pharmacokinetics (PK) and side effects. For the PK parameters a general description
rather than exact values was sufficient (i.e. ‘high protein binding’ rather than ‘98% protein
bound’). It was expected that candidates would mention the fact that clopidogrel is a pro-drug
and the factors which influence its conversion to the active form. Additional marks were
awarded for well-structured answers which attempted a comparison between the two drugs
(helped by the use of a table).