This chapter is vaguely relevant to Section G7(iii) of the 2017 CICM Primary Syllabus, which asks the exam candidate to "describe the invasive and non-invasive measurement of blood pressure, including limitations and potential sources of error". It is also loosely associated with Section G7(ii), "describe the principles of measurement, limitations, and potential sources of
error for pressure transducers, and their calibration". It represents a summary of the important concepts for the purpose of rapid revision, with a focus on arterial blood pressure measurement.
The need for such a summary is not clear in the context of the CICM Part I exam, as the examiners have only ever interrogated the trainee's understanding of these matters once, in Question 2 from the first paper of 2019. "Hydraulic coupling and transducers" formed an important part of the answer there. Overall, the subject matter seems like something foundational to ICU practice, and in his attempt to explain these issues to himself the author had written extensive notes on the subject early in his career. It seemed wasteful to destroy them, and they are reproduced here for sentimental reasons as much as for educational ones.
In summary, the components of the measurement system and their characteristics are as follows:
- An intra-arterial catheter
- Kink-resistant, biologically inert, incompressible
- Accesses the arterial circulation and provides the interface between the arterial blood and the circuit fluid
- Fluid-filled tubing
- Produces the hydraulic coupling between the arterial circulation and the pressure transducer
- Access points to allow sampling
- Flush valve
- Fluid in the tubing
- Usually, normal saline or
- Under pressure from the pressure bag to prevent blood refluxing into the line
- Counterpressure fluid bag
- Pneumatically pressurised to ~ 300mmHg to sufficiently counteract systemic arterial pressure
- Pressure transducer
- Wheatstone bridge piezoresistive transducer which converts pressure into a change of electrical current
- Signal conditioning and monitoring software
- Filters the raw signal from the transducer
- Converts it into a human-readable waveform
- Records the data in a storage medium for review
The fluid-filled transducer system used for this is the same as would be found in any other system measuring the pressure in any other fluid-filled compartment (central veins, cerebral ventricles). The physics behind this is discussed at great length in the chapter on "Pressure transducers for haemodynamic measurements" and "Resonance, damping and frequency response". These and other entries under the heading "Principles of Pressure Measurement" represent a redux of this chapter and add little to the learning process, in the same way that a four-hour director's cut adds little to the content of a motion picture which retains all of its positive qualities when cut by 50% for cinema release.
Arterial Line Transducer Setup
The arterial pressure wave travels at 6-10 metres/sec. The cannula in the artery is connected to the transducer via some non-compliant fluid-filled tubing. The transducer is usually a soft silicone diaphragm attached to a Wheatstone Bridge. It converts the pressure change into a change in electrical resistance of the circuit. This can be viewed as waveform.
Priming the non-compliant pressure tubing
The idea is that the fluid in the tubing transmits the pressure wave to the transducer - The whole principle rests on a continuous cylinder of saline connecting the artery to the pressure transducer. The design and engineering characteristics of this tubing has a significant influence on the function of the whole transducer system.
Why no more than 1.2 metres?
Long tubing underdamps the system. This may seem weird (surely, the longer the line the more plastic there is to absorb the pulse wave) but the 2013 ESICM haemodynamic learning package seems to suggest (p.36) that it is so. It is best explained in this AANA article. Essentially, the fluid-filled system has a certain "natural frequency" of resonance. The major determinant of this natural frequency is the length of the tubing: the longer the tubing, the lower the natural frequency. The patient's pulse oscillation is usually a fairly low-frequency phenomenon, and as the tubing length increases, the natural frequency approaches the patient's pulse wave frequency. The system then resonates, amplifying the signal. Thus, the longer the tubing, the more resonance in the system, and consequently the system will be underdamped. For the same reason, the tube lumen should always be no smaller than 1.5mm.
Without restating the material discussed in the chapter on resonance and damping, one can simply say that "damping is anything that has a "shock absorber" effect on the art line. Air bubbles, long tubing, or compliant tubing – all of these absorb some of the force of the pulse wave decreasing the amplitude of the oscillations. This is one of the reasons normal IV tubing is not used to set up an arterial line transducer kit: the IV tubing is too soft and compliant; the elasticity of the plastic would absorb much of the pulse wave. Damping results in a slurred waveform with overestimation of the diastolic and underestimation of systolic; however, the MAP value is usually preserved. In contrast, a kinked or clogged art line will see MAP systolic and diastolic all trending towards zero.
Zeroing and levelling the art line
Zeroing and levelling are occasionally used interchangeably, but they are not the same thing. They tend to occur together in the clinical setting, but the terms describe different processes. Zeroing exposes the transducer to atmospheric pressure via an open air-fluid interface, and levelling assigns this zero reference point to a specific position on the symbolic fluid-filled column that is the patient‘s body.
"Zeroing" can be defined as "the use of atmospheric pressure as a reference standard against which all other pressures are measured". The canonical college definition is "a process which confirms that atmospheric pressure results in a zero reading by the measurement system". The device is zeroed when the air-fluid interface is opened to atmospheric pressure (otherwise it would read diastolic blood pressures of ~ 760mmHg). Atmospheric pressure varies little between the intensivists' eye level and the supine patients' aortic root level, and so strictly speaking the zeroing of an arterial line can take place with the transducer lying anywhere. Re-zeroing must occasionally take place as both the transducer and the atmospheric pressure will gradually drift away from the calibration point.
"Leveling" can be defined as "the selection of a position of interest at which the reference standard (zero ) is set". The canonical college definition is "a process which determines the position on the patient you wish to be considered to be your zero." For reasons of convenience this tends to happen at the same time as zeroing the system to atmospheric pressure (which also sets the reference "0 mmHg" standard), but theoretically one could zero the transducer to atmosphere and then swing it wildly all around the room before levelling it against a reference point on the frightened patient.
The system is conventionally "levelled" at the phlebostatic axis, which is a reference level we have used since probably 1945. The phlebostatic axis corresponds roughly with the position of the right atrium and aortic root, and his level has generally been accepted as the ideal reference level for measure the pressure of the blood returning to the heart. It was therefore adopted as the reference level for CVP measurement. For arterial pressure measurements, at least since 2001 or so we have also been levelling the arterial lines at the phlebostatic axis. Prior to that, some units levelled their arterial lines at the level of the catheter insertion site. The specific reference point for the arterial transducer is actually the aortic root, but because it is very close to the right atrium the two reference levels are essentially the same.
The scientific basis for these reference points is murky, and relates vaguely to the idea that these are also the reference points from which your own pressure transducers (the atrial and arterial baroreceptors) "measure" the pressure for the purpose of maintaining cardiovascular homeostasis. This concept, in turn, relates to the idea of there being a "hydrostatic indifference point" where pressure and vascular wall stress remain stable irrespective of changes in body position, and which appears to be somewhere around the right atrium. There are actually distinct hydrostatic indifference points for the venous and arterial circulation, and the right atrium is probably not where they are in the normal human (that right atrial location was determined in the 1930s by rotating the bodies of dead animals), but to discuss this here would represent an unforgivable digression. More detail is available in the chapter dealing with the physiological responses to changes in posture. For the purposes of day-to-day use, the arterial line should be zeroed at the "phlebostatic axis", whatever that is.
For every 10cm below the phlebostatic axis, the art line will add 7.4mmHg of pressure.
One may sometimes be interested in levelling the arterial line at another point. Essentially, the level at which you zero the arterial line will measure the arterial pressure at that level. Which means that if your patient is in some sort of unconventional position (eg. sitting bolt upright) you may wish to measure at the level of the tragus instead. An art line levelled at the level of the external auditory meatus will measure the arterial pressure in the Circle of Willis, which is a representation of cerebral perfusion pressure. Various eminent society guidelines recommend that for the use of cerebral perfusion pressure as a therapeutic target, the reference level should be somewhere around the middle cranial fossa. Whether this matters or not is a subject of some debate.
Flushing the art line
Apparently, using heparinised saline improves accuracy somehow, but does not prolong patency. Most centres have abandoned this practice because of the increased risk of HITS. The normal rate of flow is 3ml/hr, just to keep the catheter from clotting. The flush rate of the fast flush is 30-60ml/min, so in absence of a good cannula, one can infuse the patient with a litre of flush fluid every 15-30 minutes.