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  1. Deranged Physiology
  2. CICM Primary Exam
  3. Required Reading
Pharmacodynamics
Mechanisms of Drug Action
Classification of drug actions
The law of mass action in pharmacodynamics
Receptor theory of drug action
Affinity, association constant and dissociation constant
Receptor-Effector Coupling
Structural relationships for receptors and ligands
Mechanisms of drug-receptor interaction
Regulation of drug receptor number and activity
Intracellular Second Messenger Systems
Second messenger systems
Cyclic AMP (cAMP)
Cyclic GMP (cGMP)
Calcium, inositol triphosphate and diacylglycerol
Relationship of Dose and Effect
Graded, quantal and ordered drug responses
Graded dose-response curves
Quantal dose-response curves
Therapeutic index, ED50, TD50 and LD50
Potency and efficacy
Full agonists, partial agonists and inverse agonists
Competitive and non-competitive antagonists

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