This chapter is most relevant to Section F3(i) from the 2017 CICM Primary Syllabus, which expects the exam candidates to be able to "describe the inspiratory and expiratory process involving the chest wall, diaphragm, pleura and lung parenchyma". In the CICM Part One exam, this specific phrase has never appeared in any written question or viva station, but one can easily imagine how a nebulous syllabus item like this might easily be used against the candidates in the future. And given its nebulousness, those trying to conjure an answer de novo in the heat of the moment will find themselves substantially disadvantaged. Clearly, a prefabricated response is called for, preferably one which comes with some instantly recognisable diagrams. 

The diagram below is instantly recognisable, as it is present in some form or another in most texbooks:

inspiratory and expiratory process

The events in this picture can also be described using a thousand words.

Process of normal inspiration

Diaphragm

  • By contracting, flattens and pushes the abdominal contents down, increasing the intrathoracic volume

Chest wall 

  • Inspiratory skeletal muscle contract:
    • "Bucket handle" movement: elevation of the ribs (mainly by the external intercostals)
    • "Pump handle" movement: elevation of the sternum (by the sternomastoid muscle)
  • This also increases intrathoracic volume and opposes the effect of atmospheric pressure

Pleural cavity

  • Intrapleural pressure at end of expiration is normally negative (-5 cm H2O)
  • With the contraction of inspiratory muscles, it becomes more negative (-8 cm H2O)
  • When the negative pleural pressure overcomes the elastic recoil of the lung, the lung volume also expands

Alveoli

  • As the lung volume expands during inspiration, the alveolar pressure drops to below atmospheric.
  • This produces a pressure gradient between the upper airway and the alveoli
  • This pressure gradient produces airflow into the lungs
  • At the end of inspiration, alveolar pressure equals atmospheric pressure, and there is no flow because there is no pressure gradient.

Process of normal expiration

Diaphragm

  • By relaxing, allows the chest wall and abdominal content to decrease the intrathoracic volume.
  • Abdominal muscles, by maintaining tone, put pressure on the abdominal contents and push it into the chest cavity, making the diaphragm take on a dome shape.
  • By intruding back into the chest cavity, the intrathoracic volume is decreased by the relaxation of the diaphragm. 

Chest wall 

  • Inspiratory skeletal muscle relax
  • Expiratory muscles (internal intercostals) by contracting depress the ribs.
  • Chest wall relaxes back to a resting position
  • As the chest wall decreases in diameter, the thoracic cavity decreases in volume

Pleural cavity

  • Intrapleural pressure at end of inspiration is normally negative (-8 cm H2O)
  • With the contraction of inspiratory muscles, it becomes less negative (-5 cm H2O)
  • This increase in pressure combines with the elastic recoil of the lung tissue to increase the alveolar pressure

Alveoli

  • As the lung volume contracts during expiration, the alveolar pressure increases to above atmospheric.
  • This produces a pressure gradient between the alveoli and the upper airway
  • This pressure gradient produces airflow out of the lungs
  • At the end of expiration, alveolar pressure equals atmospheric pressure, and there is no flow because there is no pressure gradient.
  • At the end of expiration, the alveolar volume is the FRC.

Pressure, flow and volume relationships during normal breathing

The diagram above, though it appears in almost every physiology textbook, actually appears to be a confabulation. None of the books ever give a reference for where they get it from. In truth, it appears that it is a concatenation of the findings from multiple studies which individually studied different aspects of respiratory mechanics.

For example, the pressure and flow waveforms were probably adapted and noise-filtered from the 1950 publication by Otis et al,  "Mechanics of Breathing in Man"The subjecs, though trained to perform these tests, were breathing with some effort, which acocunts for the relatively high values for airfow and airway pressure.

pneumotachograph recordings from Otis et al, 1950

For a relationship between pleural pressure and tidal volume, one could potentially look at the measurements acquired by Christie & McIntosh (1934) from a patient with a "minimal tuberculous lesion at the right apex", using a 1mm trochar to create a small (40ml) pneumothorax and to measure its contents.

pleural pressure recorded by Christie and McIntosh (1934)

It is notable that during expiration the pneumothorax pressure in these tracings had increased, which represents the pressure imposed upon it from the contracting thorax. In reality, it is said that pleural pressure is constantly negative, and so it must become slightly less negative during expiration.  A more realistic impression of the intrapleural pressure comes from Cherniak et al (1955), whose recordings are presented below. The authors used an oesophageal manometer balloon (some of the first) as well as a curved thin pleural needle. One can see that the pleural pressure dips as low as -8 cm H2O in inspiration, which is probably where the textbooks got their values from.

air flow and pleural pressure from Cherniak et al, 1955

One can easily step into the boots of textbook editors and see how they, confronted with high noise and poor signal, opted to clean and stylise the respiratory graphics in their representations. It is possible to make a strong argument for that sort of behaviour. The primary objective, after all, is to inspire an understanding of the basic concepts, not to represent empirical data with the greatest accuracy. Still, it sometimes helps to know where these data have come from.

References

Carlson, Betty. "Normal chest excursion." Physical therapy53.1 (1973): 10-14.

Hyatt, ROBERT E., and RAYMOND E. Flath. "Relationship of air flow to pressure during maximal respiratory effort in man." Journal of Applied Physiology 21.2 (1966): 477-482.

Otis, Arthur B., Wallace O. Fenn, and Hermann Rahn. "Mechanics of breathing in man." Journal of applied physiology 2.11 (1950): 592-607.

Kenyon, C. M., et al. "Rib cage mechanics during quiet breathing and exercise in humans." Journal of Applied Physiology 83.4 (1997): 1242-1255.

Tobin, Martin J., et al. "Breathing patterns: 1. Normal subjects." Chest 84.2 (1983): 202-205.

Bayliss, L. E., and G. W. Robertson. "The visco‐elastic properties of the lungs." Quarterly Journal of Experimental Physiology and Cognate Medical Sciences: Translation and Integration 29.1 (1939): 27-47.

Attinger, Ernst O., R. Grier Monroe, and Maurice S. Segal. "The mechanics of breathing in different body positions. I. In normal subjects." The Journal of clinical investigation 35.8 (1956): 904-911.

Macklem, Peter T. "The mechanics of breathing." American journal of respiratory and critical care medicine 157.4 (1998): S88-S94.

Rahn, Hermann, et al. "The pressure-volume diagram of the thorax and lung." American Journal of Physiology-Legacy Content 146.2 (1946): 161-178.

Mead, Jere, and James L. Whittenberger. "Physical properties of human lungs measured during spontaneous respiration." Journal of Applied Physiology 5.12 (1953): 779-796.

Ghista, D. N., K. M. Loh, and M. Damodaran. "Lung ventilation modeling and assessment." Human Respiration: Anatomy and Physiology, Mathematical Modeling, Numerical Simulation and Applications, WIT Press Series: Advances in Bioengineering 3 (2006): 95-115.

Neergaard, K. von, and K. Wirz. "Über eine Methode zur Messung der Lungenelastizität am lebenden Menschen, insbesondere beim Emphysem." Z Klin Med 105 (1927): 51-82.

Christie, Ronald V., and C. A. McIntosh. "The measurement of the intrapleural pressure in man and its significance." Journal of Clinical Investigation 13.2 (1934): 279.

Cherniack, Reuben M., et al. "A comparison of esophageal and intrapleural pressure in man." Journal of applied physiology 8.2 (1955): 203-211.

Otis, A. B., and D. F. Proctor. "Measurement of alveolar pressure in human subjects." American Journal of Physiology-Legacy Content 152.1 (1947): 106-112.