Viva 5

Name this molecule? How can we make this molecule biologically active?

Candidates were expected to recognise ‘phenylethylamine’ and appreciate that it is the
precursor molecule for the naturally occurring catecholamines. A brief overview of its
structure activity relationships, particularly with respect to substitutions on the phenyl ring, b
carbon and amine group (producing dopamine, adrenaline and noradrenaline) was expected.
Questioning then progressed to discuss the pharmacology of noradrenaline in more detail.
Changing questions, candidates were asked to provide a very brief overview of what the
autonomic nervous system was before exploring the physiology of the valsalva manoeuvre in
some detail.