- 24-year-old male day 27 in ICU with a background of Lennox-Gustaut syndrome and a recent diagnosis of acute promyelocytic leukaemia, admitted with neutropaenic sepsis and bilateral pulmonary infiltrates. He had failed weaning and had a recent deterioration with worsening hypoxia. Clinical findings included gross fluid overload, bilateral pleural effusions with left collapse/consolidation and pericardial effusion. Candidates were asked to assess him and formulate a management plan. Discussion points included weaning strategies, principles of CRRT and management of sepsis, including possible sources.