This will all be the same in any cholinergic synapse, be it neuromuscular or parasympathetic

Once again, this is one of those things best described with a humongous diagram.

acetylcholine metabolism release and storage

Drugs affecting choline reuptake
  • Hemicholinium
Drugs inhibiting acetylcholine release
  • Botulinum toxin
Drugs inhibiting acetylcholinesterase
  • Neostigmine
  • Physostigmine
  • Galantamine
  • Donepezil
  • Sarin nerve gas
  • Organophosphates


For this sort of really basic stuff, no matter where you look you will find essentially the same information.

I used chapters from "Goodman & Gilman's The Pharmacological Basis of Therapeutics" 11th ed by Brunton et al, and "Basic & Clinical Pharmacology" 11th ed. By Katzung et al.

I also perused Peck and Hill "Pharmacology for Anaesthesia and Intensive care" as well as the notoriously error-prone "Handbook of Pharmacology and Physiology in Anaesthetic Practice" by Stoelting and Hillier. Neither covered this subject in a depth I found satisfying.

Goodman and Gilman's remains a canonical text.