Friday, February 26 (2021); Cardiovascular system
Vasopressin is an endogenously available vasoconstrictor with antidiuretic effects. "Vasopressor effects are exerted by V1 receptors, which are Gq-protein coupled receptors. Similarly to alpha-1 receptors, they increase intracellular calcium by means of increasing cAMP concentrations. V2 receptors are Gs-coupled receptors and produce the insertion of aquaporins into the apical membrane of principle cells of the collecting tubule, promoting the retention of watr.
Unlike catecholamine receptors, vasopressin receptors do not lose their affinity for vasopressin with changing pH."