A free online resource for Intensive Care Medicine.
An unofficial Fellowship Exam (CICM Part 2) preparation resource.
Deranged Physiologyis a slowly growing archive of discussions and study notes relevant (or if not relevant, then at least interesting) to the practice of intensive care medicine. The content provides an introduction to the fundamental themes in intensive care: mechanical ventilation, vasopressors, electrolyte management, hemodynamic monitoring, dialysis, and so forth. Attention is directed at equipment in intensive care, and there are attempts to revisit interesting pharmacology and physiology. The aim of this resource is to supplement the bedside teaching of senior staff, and to consolidate resources for intensive care trainees in the initial stages of their training.
Bone and connective tissue contain 15% of the total body fluid (that's 9% of the mass of the organism) but they are slow to mobilise and wont participate in infusion physiology to a relevant degree. The rest is the functional ECF.
Functional ECF is about 30% of the total body fluid, or about 20% of total body mass (18% to be precise)
Osmotic pressure has already been introduced as the hydraulic pressure required to prevent the migration of solvent from the area of low solute concentration to an area of high solute concentration. The below diagram also describes the Van 't Hoff equation.
The conjugate base of acetic acid, acetate is mated to a sodium cation instead of hydrogen. If one were to speak like a real scientist one might say that sodium acetate is the sodium salt of acetic acid. Cheap junk food manufacturers occasionally use it in lieu of actual salt and vinegar.
This is a one molar solution of sodium bicarbonate. That is to say, one litre of this stuff contains one mole (84g ) of sodium bicarbonate.
Given that in solution it dissociates into two particles, the osmolality is actually 2 Osm/kg. Yes, 2000 mOsm/Kg. This is another solution which is unkind to peripheral veins. The 100ml bottles of 8.4% bicarbonate contain 100mmol.