Question 11

A 50-year-old patient is electively admitted to HDU following a bowel resection. They have longstanding tetraplegia with a neurological level of injury at C5.
a) Outline the clinical signs of autonomic dysreflexia (also referred to as autonomic hyperreflexia). (3 marks)
b) Outline strategies to prevent autonomic dysreflexia in this patient. (4 marks)
c) Outline your management of autonomic dysreflexia in this patient. (3 marks)

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College answer

Syllabus topic/section:

2.1.13 Trauma Intensive Care / Spinal trauma: L1
2.1.8 Neurological Intensive Care / Spinal cord disorders: L1

Discussion:  

Candidates who had a good knowledge of longstanding tetraplegia and the corresponding pathophysiology did well. Candidates who had limited knowledge of the disorder but were able to apply general knowledge of management of spinal patients (e.g. bowel care and patency of IDC- very important in this patient population) were able to gain some marks.
The marking rubric is included to aid the candidate's future
study

Domain

Below standard

At standard

Above standard

a.

Manifestations of autonomic dysreflexia

(3 marks)

Lacking detail; incorrect or missing parts of answer

0-1.0 marks

Good level of detail and understands clinical syndrome.

1.5-2.0 marks

Detailed, nuanced answer, understands variety of manifestations

2.5-3.0 marks

b. Prevention

(4 marks)

Inadequate detail/ superficial answer/incorrect answer

0-1.5 marks

Detailed response

Safe approach to prevention including consideration of positioning, analgesia, bladder and bowel care

2.0-2.5 marks

Contains applied clinical perspective.

Able to outline in detail prevention in context of patient described

3.0-4.0 marks

c. Treatment

(3 marks)

Inadequate detail/ superficial answer or incorrect

0-1.0 marks

Reasonable level of detail present

Safe approach to management including monitoring for complications

1.5-2.0 marks

Contains applied clinical perspective and well thought through, detailed approach to management

2.5-3.0 marks

Discussion

  • Clinical features:
    • Headache
    • Dizziness
    • Nausea
    • Shortness of breath
    • Visual disturbances
    • Palpitations
    • Facial flushing, nasal congestion and sweating above the spinal lesion (baroreceptor-mediated vasodilatation)
    • Cold clammy skin with piloerection below the lesion level 
    • "Autonomic conflict"- cardiac arrhythmias arising from competing massive sympathetic and concurrent vigorous parasympathetic activity
    • Hypertension is the dominant finding, and leads to complications, such as:
      • Myocardial ischaemia and pulmonary oedema
      • PRES and intracranial haemorrhage
      • Seizures
  • Prevention strategies:
    • A - if the patient was intubated, you would extubate as soon as able, as these patients will have frequent episodes of dysreflexia in reaction to the ETT. If not intubated, they would have an NGT, and it would be a priority to remove oit.
    • B - avoid noxious airway stimuli, eg. suctioning 
    • C- Keep the circulating volume in the lower body by raising the head of the bed
    • D - even though there is no pain sensation, analgesia helps prevent noxious stimuli from triggering the episodes. 
    • E - Maintain normal electrolytes so as not to give the gut a chance to do an ileus
    • F - maintain good urine output, support good hydration, prevent urinary retention by intermittent catheterisation.
    • G - Maintain regular bowel regime with aperients and enemas (the goal is to prevent constipation)
  • Management:
    • During a hypertensive crisis, 
      • Lower the legs and elevate the head (Trendelenburg position)
      • Check the usual suspects:
        • Tight binding clothes
        • Urinary catheter/bladder (retention?)
        • Bowels (constipation?)
        • Pain (give empirical analgesia)
      • Use short-acting titratable agents:
    • Long term:
      • Botox injections
      • Intravesical capsaicin
      • Transurethral sphincterotomy
      • Sacral bladder denervation via dorsal rhizotomies 
      • Malone anterograde continence enema (MACE)

References

Sober-Williams, Elin K., et al. "Dysreflexic dilemma: do we need a revised definition for autonomic dysreflexia?." Clinical Autonomic Research (2024): 1-9.

Karlsson, A. K. "Autonomic dysreflexia." Spinal cord 37.6 (1999): 383-391.

Wecht, Jill M., et al. "International standards to document autonomic function following SCI (ISAFSCI)." Topics in Spinal Cord Injury Rehabilitation 27.2 (2021): 23-49.

Weaver, Lynne C., et al. "Autonomic dysreflexia after spinal cord injury: central mechanisms and strategies for prevention." Progress in brain research 152 (2006): 245-263.

Krassioukov, Andrei, et al. "Evaluation and management of autonomic dysreflexia and other autonomic dysfunctions: Preventing the highs and lows: Management of blood pressure, sweating, and temperature dysfunction." Topics in Spinal Cord Injury Rehabilitation 27.2 (2021): 225-290.

Eldahan, Khalid C., and Alexander G. Rabchevsky. "Autonomic dysreflexia after spinal cord injury: Systemic pathophysiology and methods of management." Autonomic Neuroscience 209 (2018): 59-70.