| Class | Chronotrope |
|---|---|
| Chemistry |
Phenylethylamine |
| Routes of administration |
IV |
| Absorption |
Oral bioavailability 33% |
| Solubility |
pKa = 8.96, good water solubility |
| Distribution |
VOD= 1.5L/kg, 14-18% protein-bound |
| Metabolism |
A poor substrate by MAO, but is easily and rapidly metabolised by COMT |
| Elimination |
Minimal free drug is eliminated in the urine |
| Time course of action |
Half-life is 2 minutes |
| Target receptor |
Beta-1 and beta-2 noradrenaline receptors |
| Mechanism of action |
By acting mainly on beta-1 and beta-2 receptors, isoprenaline mostly acts by increasing cAMP in smooth muscle |
| Clinical effects |
Tachycardia, vasodilation, increased cardiac contactility, bronchodilation, hyperlactataemia and hyperglycaemia |
| Literature reference |
Szymanski et al, 2023 |
| CICM details of understanding | Level 3 |
| Mentioned around Deranged Physiology | |
| Related SAQs |