Management of Hyponatremia

Management of hyponatremia ranges from stopping inappropriate water intake to using sophisticated V2-antagonist drugs to abolish the effects of vasopressin on the cortical collecting duct. The college loves this topic, because inevitably hypertonic saline comes up as a topic of discussion. With it, one can ask about calculation of the sodium deficit, and possibly also about the complications of rapid correction (i.e. osmotic demyelination). The reason for this interest is largely due to the frequency with which hyponatremia becomes an ICU issue. Referrals are made by endocrinologists who have a hyponatremic patient. The endocrinologist is anxious and wants to replace sodium, but does not wish to take responsibility for the myelinolysis. It is much easier to defer the matter to intensive care doctors, who will make all the decisions and take all the blame when the patient's white matter structures dissolve into a jelly.

  • Question 24 from the first paper of 2016 (management of severe hyponatremia)
  • Question 1 from the second paper of 2010 (hypertonic saline as osmotherapy and as sodium replacement)
  • Question 14 from the first paper of 2005 (sodium replacement and approach to diagnosis )
  • Question 7 from the second paper of 2002 (diagnosis and management of hyponatremia)
  • Question 5.2 from the second paper of 2011 (pontine myelinolysis)

In this context, the classification of hyponatremia by volume status is actualy helpful. The reason is that it can now guide management. For instance, it helps decide whether you restrict fluid intake or replace volume with isotonic saline.

The best literature reference for management options is probably the recent overview of published guidelines by Verbalis et al (2014).

Fluid restriction

This is the management of choice for patients with euvolemic and hypervolemic hyponatremia. Essentially, in SIADH and in the organ system failure states (eg. CCF, cirrhosis and nephrotic syndrome) the body water volume is inappropriately elevated, and the only appropriate response is to decrease the mount of water intake. Also, restricting fluid intake for the psychogenic water drinker and the beer potomaniac seems like a sensible thing to do.

What features might give you the impression that fluid restriction by itself is not going to work?

  • High urine osmolality
  • Low urine output
  • Sum of urinary sodium and potassium concentrations exceeds the serum sodium concentration
  • After 2 days of fluid restriction, the sodium concentration has failed to increase by more than 2 mmol/L

Isotonic saline replacement

This is the manegement of choice for patients with hypovolemic hyponatremia. Their hyponatremia is in part due to the escalation of ADH secretion in response to their low circulating volume. Without volume replacement, sodium replacement in these people is going to be ineffective. Question 5.1 from the second paper of 2011 presents just such a scenario, where a thiazide-poisoned woman is managed with isotonic saline. Once volume is corrected, the stimulus for ADH secretion will cease; the osmostat will then restore tonicity by massive diuresis.

In summary:

  • Hypovolemia has resulted in excess ADH release in spite of hypo-osmolarity, because the baroreceptor reflex is a stronger stimulus for ADH release than the osmoreceptor reflex.
  • The excess ADH results in free water retention, which counteracts the attempts to increase sodium concentration with hypertonic saline
  • Once volume is restored, ADH release will decrease, and dilute diuresis will ensue
  • This loss of free water will assist the attempts to correct hyponatremia with hypertonic saline
  • Thus, volume replacement must occur together with sodium replacement.

Hypertonic saline replacement

It is straightforward: one wants to replace the missing electrolyte. However, it may not be the first line therapy.

In brief summary:

  • Sometimes, fluid restriction or other conservative measures may not be enough
  • Severe prolonged hyponatremia is not without consequences
  • Hyponatremia may have lifetheatening symptoms (such as coma and seizures), for which sodium replacement is the only sensible solution.
  • Symptomatic hyponatremia should be managed with the infusion of hypertonic saline, so as to contribute sodium without contributing volume.

Rapid correction of hyponatremia in patients with severe symptoms

In their answer to Question 24 from the first paper of 2016, the college recommend to raise the sodium level by 2-4% over 30 minutes if the patient is symptomatic, i.e. confused or having seizures. This is consistent with the recent European guidelines (Spasovski et al, 2014). The guideline development group felt that the risk of brain oedema outweighs the risk of osmotic demyelination syndrome. Specifically, they recommend the infusion of 150ml of 3% saline over 20 minutes, then checking the sodium, and then repeating the infusion.

Complications of hypertonic saline therapy

One review of 3% saline among neuroICU patients has a nice table (Table 1) which lists the potential adverse effects of hypertonic saline administration. I will reproduce the relevant parts of this table below. As you can see, the college answer for this section relies significantly on a source either identical to this one, or very closely resembling it.

  • Hyperosmolarity
  • Overshoot hypernatremia
  • Congestive heart failure and pulmonary oedema
  • Hypokalemia
  • Normal anion gap metabolic acidosis
  • Coagulopathy
  • Phlebitis (hypertonic saline is a sclerosant)
  • Renal failure (due to vasoconstriction)
  • Decreased level of consciousness
  • Rebound intracranial hypertension
  • Seizures
  • Central pontine myelinolysis
  • Subdural and intraparenchymal hemorrhage

Calculating the sodium deficit

Question 14 from the first paper of 2005 asked the candidates to calculate the sodium deficit.

The equation is reasonably straightforward:

Sodium deficit = 0.6 ×body weight × (desired concentration - current concentration)

The multiplier of body weight is 0.6 for men and 0.5 for women (whose fraction of body water is smaller)

Thus, a elderly 70kg  lady whose sodium is 100mmol/L and whom you want to be around 130 mmol/L will require around 35 × 30 mmol of sodium, or around 1050mmol in total. That would be around 300ml of 20% concentrated saline.

A generic rule of thumb is that a 70kg person (whatever the gender) will require about 10ml (34mmol) of 20% saline for every 1mmol rise in sodium, all other things being equal; and therefore a sensible safe rate of replacement is about 4-5ml/hr of 20% saline for the first 24 hours. That would be wbout 25-35 ml/hr of 3% saline, if that is all you have available.

Osmotic demyelination syndrome

This is the major danger of correcting sodium too quickly.

A few points:

  • The pons is not unique and you can myelinolyse anywhere there is myelin (Martin, 2004)
  • Sodium is not unique and osmotic demyelination can occur in a variety of other scenarios, eg. with large changes in urea or glucose. .However, it is for some reason rare in diabetes and dialysis, in spite of the comparatively massive osmotic shifts.
  • You don't need to give hypertonic saline to demyelinate the pons: you can do that with rapid autocorrection, eg. when you cease the drug that was causing the SIADH.

Risk factors for pontine myelinolysis?

 The first study (1959) which described this syndrome found it among alcoholic and malnourished patients. Later works extended the range of risk factors. In summary, they are as follows:

  • Alcoholism
  • Malnutrition
  • Other electrolyte disturbances (esp. hypokalemia)
  • Use of diuretics
  • Liver transplantation

Almost all patients who develop osmotic demyelination presented with a sodium of under 120, which means that this should probably be the threshold for concern. Of those who develop it at a sodium of over 120, the majority of cases are in patients undergoing liver transplantation.

Clinical manifestations are usually delayed for a few days (2-6 days), and are usually irreversible:

  • Dysarthria
  • Dysphagia
  • Flaccid paraparesis or quadriparesis
  • Behavioural disturbance, resembling delirium
  • Lethargy
  • Coma, obtundation
  • A "locked in" state
  • Seizures

The key issue is rate of correction.

  • If the hyponatremia has lasted longer than 48 hours, we would be forced to call it "chronic". It takes brain cells about 48 hours to get rid of idiogenic osmoles and become isotonic with the hyponatremic extracellular fluid. However, once lost, those organic molecules take much longer to synthesise.
  • In short, your adaptation to hyponatremia is rapid, but your adaptation to a rising sodium is sluggish.
  • The rate of replacement over 24 hours is more important than the rate at any specific hour.
  • According to UpToDate, " Demyelinating lesions in experimental animals are most common and most severe when the serum sodium concentration in severe hyponatremia is raised more than 20 meq/L in 24 hours and are rare at a rate below 9 meq/L in 24 hour " (they reference Soupart et al, 1992)

Pharmacotherapy for hyponatremia

Loop diuretics

In hypervolemic states (eg. cirrhosis and heat failure) loop diuretics will help with the hyponatremia at the same time as managing cardiac preload and exerting other advantageous effects. There just happens to be a greater excretion of water than of salt, particularly if you have not disabled the aldosterone receptors with spironolactone. In that sense, loop diuretics remain an effective therapy for hyponatremia. Unfortunately they sip water straight from the circulating volume, and the "apparent" decrease in this volume is the potent stimulus for ADH release in hypervolemic hyponatremia. In that sense, diuretics may be counterproductive.

Hydrocortisone

Corticosteroids have a mineralocorticoid effect. Hydrocortisone is cheap, and can be used for such an effect. One might questio the use of a steroid drug purely to have the benefit of its side effects, but this has been done. Katayama et al (2007) used it to promote volume retention in SAH patients treated with the now-defunct HHH therapy. Nothing exciting happened to mortality (probably because HHH therapy is useless) but the sodium was certainly normal in both survivors and non-survivors.

Fludrocortisone

As a synthetic mineralocorticoid, fluidrocortisone represents a form of cheating. It will cause sodium retention to outpace water retention. The only situation where it is indicated is cerebral salt wasting syndrome, where it encourages sodium retention.

Specific drug therapies for SIADH

These are discussed at greater length in the SIADH chapter. In brief, these therapies are:

  • Demeclocycline (oral)
  • Tolvaptan or satavaptan (oral)
  • Conivaptan (IV)
  • Lithium (oral)
  • Loop diuretics (oral or IV)
  • Urea (oral)

 

References

Lee, Jennifer Ji Young, et al. "Management of hyponatremia." Canadian Medical Association Journal 186.8 (2014): E281-E286.

Lazaridis, Christos, et al. "High-Osmolarity Saline in Neurocritical Care: Systematic Review and Meta-Analysis*." Critical care medicine 41.5 (2013): 1353-1360.

Adrogué, Horacio J. "Consequences of inadequate management of hyponatremia." American journal of nephrology 25.3 (2005): 240-249.

Froelich, Matteus, et al. "Continuous hypertonic saline therapy and the occurrence of complications in neurocritically ill patients*." Critical care medicine 37.4 (2009): 1433-1441.

R J Martin Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes J Neurol Neurosurg Psychiatry 2004;75:iii22-iii28 doi:10.1136/jnnp.2004.045906

Sumit Kumar, Tomas Berl. Sodium.  The LancetVolume 352, Issue 912318 July 1998Pages 220-228

Laureno, Robert, and Barbara Illowsky Karp. "Myelinolysis after correction of hyponatremia." Annals of Internal Medicine 126.1 (1997): 57-62.

Lee, Eun Mi, et al. "Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation." European neurology 62.6 (2009): 362-368.

Adams, Raymond D., MAURICE VICTOR, and ELLIOTT L. MANCALL. "Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients." AMA Archives of Neurology & Psychiatry 81.2 (1959): 154-172.

Brown, William D. "Osmotic demyelination disorders: central pontine and extrapontine myelinolysis." Current opinion in neurology 13.6 (2000): 691-697.

Harris, Cheryl P., J. J. Townsend, and J. Richard Baringer. "Symptomatic hyponatraemia: can myelinolysis be prevented by treatment?." Journal of Neurology, Neurosurgery & Psychiatry 56.6 (1993): 626-632.

Katayama, Yoichi, et al. "A randomized controlled trial of hydrocortisone against hyponatremia in patients with aneurysmal subarachnoid hemorrhage." Stroke 38.8 (2007): 2373-2375.

Verbalis, Joseph G., et al. "Review and analysis of differing regulatory indications and expert panel guidelines for the treatment of hyponatremia." Current medical research and opinion 30.7 (2014): 1201-1207.

Soupart, Alain, et al. "Treatment of chronic hyponatremia in rats by intravenous saline: comparison of rate versus magnitude of correction." Kidney international 41.6 (1992): 1662-1667.

Spasovski, Goce, et al. "Clinical practice guideline on diagnosis and treatment of hyponatraemia." European Journal of Endocrinology 170.3 (2014): G1-G47.