These are the methods of discriminating the patients who are malnourished or who are at risk of malnutrition during their ICU stay. In short, one makes a "subjective global assessment of nutritional status" on the basis of history and examination, and then collects supporting anthropometric and laboratory data, which can be used to monitor response to therapy. Previous SAQs on this topic have included:

An approach to the assessment of nutritional status


  • Premorbid weight and the pattern of its change
  • Premorbid nutritional routine
  • Diseases affecting gastrointestinal function (eg. coeliac disease)
  • Disease affecting satiety control (eg. Prader-Willi syndrome)
  • Factors influencing metabolic substrate utilisation (eg. thyroid dysfunction, hypoadrenalism, Cushings disease or corticosteroid therapy)


  • Observed quality of nails and hair (an indicator of chronic protein intake)
  • Subcutaneous fat measurements (triceps)
  • Muscle bulk and muscle tone of quadriceps and deltoids
  • Presence of oedema and ascites
  • Evidence of any specific micronutrient deficiency


  • BMI
  • Ideal body weight
  • Lean body mass

Biochemistry and physiology:

  • Cholesterol and triglycerides
  • Random BSL
  • HbA1C
  • Serum cortisol
  • TFTs
  • FBC for lymphocyte count
  • Albumin and prealbumin
  • Transferrin
  • Calculation of nitrogen balance
  • Micronutrient levels:
    • Fat-soluble vitamins A, D and E
    • Thiamine
    • Zinc
    • Selenium
    • Vitamin B12
    • Folate
  • Delayed hypersensitivity skin-testing

Subjective Global Assessment of Nutritional Status

This technique is a wholistic history-and-examination guided method of classifying a patient as well nourished, moderately malnourished, or severely malnourished. It can be combined with supportive anthropometric indices, and with biochemical analysis of endocrine and metabolic function.


The value of albumin as an indicator of chronic nutritional status

In short, it has none. Even the patholgists agree. Albumin is what one might call a "negative acute phase protein", and one's production of albumin is among the first frivolities sacrificed by the fascist austerity measures of the hypercatabolic stress response. In critical illness, the serum albumin is not a reliable measure of nutritional status, because (almost by definition) everybody in ICU is sufficiently unwell to have a vigorous stress response, and markedly diminished albumin production. It is probably more related to the severity of the illness (by magnitude of its decrease, rather like a magnitude of increase in the CRP). However, it has seemed attractive in the past, because its production is also sacrificed in chronic malnutrition, and it has a long halflife.

The value of prealbumin as an indicator of recent nutritional status

Prealbumin is perhaps slighly more useful than albumin as a means of assessing recent nutrition. Its halflife is only 2 days, which means that its levels will fall rapidly if your stressed-out body has recently prioritised the synthesis of CRP and fibrinogen. In fact, it seems prealbumin levels are inversely proportional to CRP. So in ICU a single prealbumin level is probably meaningless. However, sequential measurements can be used to assess the adequacy of nutritional support. There has been at least one study which has demonstrated that for an ICU patient, an increase in prealbumin indicates that at least 65% of protein-energy needs have been met.

Investigations of uncertain value and experimental interest

Calculation of nitrogen balance

The equation for calculating nitrogen balance is as follows:

nitrogen balance equation

Obviously, the inconvenience of 24-hour urine collection and the wild inaccuracy of this tecnique have limited its clinical use. The errors tend to overestimate intake and underestimate output, thereby leading to falsely positive balances. Intake, after all, is dependent on a working gut (and who in the ICU can confidently report one of those?). Urinary output can be measured, but what of sweat and faecal losses? And what if the patient produces no urine? Don't get me started on nitrogen balance in dialysis.

Delayed skin hypersensitivity testing

The repsonse to skin-prick hypersensitivity testing is a very indirect method of assessing ntritional status. It rests on the premise that malnutrition results in decreased lymphocyte number and function, which in turn will result in a delayed response to skin-prick testing. This has been observed in 1973 among malnourished children, an it is possible that somebody somewhere did this routinely to adults, but interest in this practice has been lost since perhaps the early 1980s, and now it is only found in CICM college answers.

References is an excellent resource for all things nutrition-related.

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Dhaliwal, Rupinder, et al. "The Canadian Critical Care Nutrition Guidelines in 2013 An Update on Current Recommendations and Implementation Strategies."Nutrition in Clinical Practice 29.1 (2014): 29-43.

de Souza Menezes, Fernanda, Heitor Pons Leite, and Paulo Cesar Koch Nogueira. "Malnutrition as an independent predictor of clinical outcome in critically ill children." Nutrition 28.3 (2012): 267-270.

Norman, Kristina, et al. "Prognostic impact of disease-related malnutrition."Clinical nutrition 27.1 (2008): 5-15.

Detsky, Allan S., et al. "What is subjective global assessment of nutritional status." JPEN J Parenter Enteral Nutr 11.1 (1987): 8-13.

Sauberlich, Howerde E. Laboratory tests for the assessment of nutritional status. Vol. 21. CrC Press, 1999.

Gorstein, Jonathan, et al. "Issues in the assessment of nutritional status using anthropometry." Bulletin of the World Health Organization 72.2 (1994): 273.

Shenkin, Alan. "Serum prealbumin: Is it a marker of nutritional status or of risk of malnutrition?." Clinical chemistry 52.12 (2006): 2177-2179.

Ritchie, Robert F., et al. "Reference distributions for the negative acute‐phase serum proteins, albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort." Journal of clinical laboratory analysis 13.6 (1999): 273-279.

Desborough, J. P. "The stress response to trauma and surgery." British journal of anaesthesia 85.1 (2000): 109-117.

Klein, S. "The myth of serum albumin as a measure of nutritional status."Gastroenterology 99.6 (1990): 1845.

Don, Burl R., and George Kaysen. "Poor nutritional status and inflammation: serum albumin: relationship to inflammation and nutrition." Seminars in dialysis. Vol. 17. No. 6. Blackwell Science Inc, 2004.

Schoenfeld, Patricia Y. "Albumin is an unreliable marker of nutritional status."Seminars in Dialysis. Vol. 5. No. 3. Blackwell Publishing Ltd, 1992.

Shenkin, A., et al. "Laboratory assessment of protein-energy status." Clinica chimica acta 253.1 (1996): S5-S59.

Clark, Matthew A., et al. "Sequential changes in insulin-like growth factor 1, plasma proteins, and total body protein in severe sepsis and multiple injury."Journal of Parenteral and Enteral Nutrition 20.5 (1996): 363-370.

Casati, A., et al. "Rapid turnover proteins in critically ill ICU patients. Negative acute phase proteins or nutritional indicators?." Minerva anestesiologica 64.7-8 (1997): 345-350.

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Edelman, Robert, et al. "Mechanisms of defective delayed cutaneous hypersensitivity in children with protein-calorie malnutrition." The Lancet301.7802 (1973): 506-509.

Twomey, Patrick, Diana Ziegler, and John Rombeau. "Utility of skin testing in nutritional assessment: a critical review." Journal of Parenteral and Enteral Nutrition 6.1 (1982): 50-58.