Prothrombinex

Prothrmbinex

 Purified Factors II, IX and X. ..And a little VII.

thus, it all but replaces the Warfarin- induced factor deprivation.

Some factor VII will still have to come from somewhere.

The bleeding warfarinized patient will probably need some of this, as well as some FFP (probably 1 unit) to replace the Factor VII, as well as Vitamin K to ensure there will be more endogenously synthesized factors to follow.

The usual dose is 15-30 IU/kg

The maximum dose (for vigorous bleeding) is 50 IU/kg

References

For details of reversal of anticoagulation, I direct you all to the NHMRC guidelines:

Clinical practice guidelines on the use of blood components (2001)