Infectious Diseases, Antibiotics and Sepsis

Resuscitation of Septic Shock
Resuscitation of the Septic Shock Patient
Critique of the Surviving Sepsis guidelines
Critique of early goal-directed therapy protocol for sepsis
Fluid resuscitation for septic shock
Noradrenaline in resuscitation of septic shock
Vasopressin in resuscitation of septic shock
Inotropes in resuscitation of septic shock
Corticosteroids in septic shock
Management of super-refractory septic shock
Significance of the endothelial glycocalyx
Critique of obsolete definitions for sepsis and SIRS
Critique of the modern definitions for sepsis (Sepsis-III)
The difficulty in making a diagnosis of sepsis
Biomarkers of sepsis
Pathogenesis of multi-organ system failure in sepsis

Antimicrobial Pharmacology
Pharmacokinetics of antibiotics in critical illness
Antibiotic dosing in renal failure
Antibiotic dosing during dialysis
Kill characteristics of antibiotic agents
Antibiotic dosing as continuous infusion
Causes of antibiotic treatment failure
General principles and common errors of antibiotic use
The minimum inhibitory concentration (MIC)
Post-antibiotic effect
Antibiotic agents classified by mechanism of action
Specific antibiotic choices for selected pathogens
Pharmacology of antifungal agents

Specific Infectious Diseases in ICU
Microorganisms organised by Gram stain and metabolism
Acronymous organisms: ESCAPPM and HACEK
Aspergillosis
Tetanus
Candida - albicans and non-albicans
H1N1 "Swine Flu" influenza, SARS and MERS
COVID-19
Cytomegalovirus
Varicella zoster virus and VZV pneumonia
Tuberculosis
Human immunodeficiency virus (HIV) and AIDS
Coagulase-negative Staphylococci
Staphylococcus aureus bacteraemia

Tropical Infectious Diseases in the ICU
Leptospirosis
Malaria
Typhoid fever
Cholera
Viral haemorrhagic fever- Dengue and Ebola
Arboviral encephalitis
Zika virus in critical care

Scenarios in Critical Care Infectious Diseases
Infectious and non-infectious causes of fever
Pneumococcal meningitis
Meningitis in general
Meningococcal sepsis
Differential diagnosis of purpura fulminans
Necrotising fasciitis
Spontaneous bacterial peritonitis
Faecal peritonitis
Toxic shock syndrome
Acalculous cholecystitis
Ascending cholangitis
Infective endocarditis
Community-acquired pneumonia
Empyema
Sepsis in the post-splenectomy patient
Sepsis in the bone marrow transplant recipient
Sepsis in the heart and lung transplant recipient
Sepsis in the neutropenic host
Immune suppression and immunodeficiency
Septic encephalopathy
The staff member with a needle stick injury

Nosocomial Infections and Infection Control
Antibiotic stewardship in the ICU
Nosocomial infections in the ICU
Infection control strategies for critically ill patients
Ventilator-associated pneumonia (VAP)
Selective digestive tract decontamination (SDD)
Clostridioides difficile
Central line-associated bacteraemia
The meaning of positive blood cultures taken from a CVC
Implications of increasing antibiotic resistance on ICU practice
Strategies to prevent the transmission of multi-resistant organisms
Vancomycin-Resistant Enterococcus (VRE)
Methicillin-resistant Staphylococcus aureus (MRSA)
Multidrug-resistant Gram negative organisms