The asplenic state is a favourite topic of the examiners. Septic complications of asplenia featured in Question 9 from the first paper of 2013. Question 12 from the second paper of 2008 asked about pneumococcal meningitis in the post-splenectomy patient.
The functions of the spleen are briefly visited in this 2011 paper, and explored to great depth in this comprehensive review article from Nature.
In brief:
You probably had it removed.
Reasons for this include:
Alternatively, it may be congenitally absent.
How much spleen do you need for normal phagocytic function? Well. Apparently, 80-90% of an enlarged spleen can be removed without any adverse immunological consequence; the remnants (or heterotopic bits of a fragmented spleen) can regrow in a disorganised fashion around the peritoneum in a process termed "splenosis". It seems only about 30ml of splenic tissue is required for reasonably normal function.
One can also have a normal-looking spleeen and be functionally asplenic. The linked article contains a nice table, listing various differentials:
|
|
In case you were wondering, thorium dioxide was at one stage used as a radiological contrast medium.
The asplenic man is prone to infections by encapsulated organsisms.
Again, the usual culprits include the following:
Unusual culprits also include:
Key features of this immunocompromised condition:
Empirical therapy consists of:
The vaccinations prevent severe infection by encapsulated organisms - because the encapsulated organisms are poorly opsonised by complement, and the spleen was the only organ which could remove them. Thus, one must protect this patient from these bugs. There has been a 2011 revision of the guidelines for such prophylaxis:
Kastenbauer, Stefan, and Hans‐Walter Pfister. "Pneumococcal meningitis in adults Spectrum of complications and prognostic factors in a series of 87 cases." Brain 126.5 (2003): 1015-1025.
Selby, C. D., and P. J. Toghill. "Meningitis after splenectomy." Journal of the Royal Society of Medicine 82.4 (1989): 206-209.
Fraser, David W., et al. "Risk factors in bacterial meningitis: Charleston County, South Carolina." Journal of infectious Diseases 127.3 (1973): 271-277.
Reefhuis, Jennita, et al. "Risk of bacterial meningitis in children with cochlear implants." New England Journal of Medicine 349.5 (2003): 435-445.
Lynch 3rd, J. P., and George G. Zhanel. "Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention." Seminars in respiratory and critical care medicine. Vol. 30. No. 2. 2009.
Cadili, Ali, and Chris de Gara. "Complications of splenectomy." The American journal of medicine 121.5 (2008): 371-375.
Di Sabatino, Antonio, Rita Carsetti, and Gino Roberto Corazza. "Post-splenectomy and hyposplenic states." The Lancet 378.9785 (2011): 86-97.
Hirsh, J., J. A. McBride, and J. V. Dacie. "Thrombo-embolism and increased platelet adhesiveness in post-splenectomy thrombocytosis." Australasian annals of medicine 15.2 (1966): 122-128.
Davies, John M., et al. "Review of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen: Prepared on behalf of the British Committee for Standards in Haematology by a Working Party of the Haemato‐Oncology Task Force." British journal of haematology 155.3 (2011): 308-317.
Khan, Palwasha N., et al. "Postsplenectomy reactive thrombocytosis."Proceedings (Baylor University. Medical Center) 22.1 (2009): 9.
Mebius, Reina E., and Georg Kraal. "Structure and function of the spleen."Nature Reviews Immunology 5.8 (2005): 606-616.
Bader-Meunier, Brigitte, et al. "Long-term evaluation of the beneficial effect of subtotal splenectomy for management of hereditary spherocytosis." Blood 97.2 (2001): 399-403.
Fremont, Richard D., and Todd W. Rice. "Splenosis: a review." Southern medical journal 100.6 (2007): 589-593.
Corazza, G. R., et al. "Return of splenic function after splenectomy: how much tissue is needed?." BMJ 289.6449 (1984): 861-864.
Laub, M. I. C. H. A. E. L., et al. "Spleen emptying and venous hematocrit in humans during exercise." Journal of Applied Physiology 74.3 (1993): 1024-1026.
Kita, Jun, and Yasuo Itazawa. "Release of erythrocytes from the spleen during exercise and splenic constriction by adrenaline infusion in the rainbow trout."Japanese Journal of Ichthyology 36.1 (1989): 48-52.
Schwartz, Paul E., et al. "Postsplenectomy sepsis and mortality in adults."Jama 248.18 (1982): 2279-2283.
Hansen, Katrine, and Don B. Singer. "Asplenic-hyposplenic overwhelming sepsis: postsplenectomy sepsis revisited." Pediatric and Developmental Pathology 4.2 (2001): 105-121.
Holdsworth, R. J., A. Cuschieri, and A. D. Irving. "Postsplenectomy sepsis and its mortality rate: actual versus perceived risks." British Journal of Surgery 78.9 (1991): 1031-1038.
Brigden, Malcolm L., and Andy L. Pattullo. "Prevention and management of overwhelming postsplenectomy infection-an update." Critical care medicine27.4 (1999): 836-842.
van Kaick, Gerhard, et al. "The German Thorotrast study: Recent results and assessment of risks." Radiation research 152.6s (1999): S64-S71.