Given that ventilation is not a consequence-free process, one might imagine that the process of being ventilated for an unnaturally long time might result in some significant lifestyle changes.
There is a study reporting on the association between duration of ventilation and mortality. Prolonged ventilation (when defined as a ventilation time of more than 21 days) seems to be associated with a 1-year mortality of 52%. Quality of life of the survivors is also poor. However, of those surviving after 3 years roughly 99% report a return to baseline function (which probably means they were good quality protoplasm).
Othr complications of prolonged ventilation include the following: