Pharmacology and toxicology

By Alex Yartsev - 14/07/2015

Offered below is an organised list of summaries on the topic of pharmacology and toxicology from the Critical Care Compendium, courtesy of LITFL. Given the mixture of topics, the ideal audience for this material is the final stage exam candidate pursuing dual CICM and ACEM fellowship qualifications.

Pharmacology and Toxicology in the Critical Care Compendium
Toxicology and pharmacology broadly Toxicology literature summaries Toxic agents and abnormal vital signs Adverse drug reactions Drug infusion doses Epidural complications Rib fracture epidural versus opioids gastrointestinal drug absorption in critical illness Pharmacology and Critical Illness Obesity and pharmacokinetics Weights in Pharmacology Approach to acute poisoning ECG in Toxicology Evidence-based Toxicology Antidotes and forced enhanced clearance Antidote Summary flumazenil naloxone physostigmine Enhanced elimination activated charcoal Alkali therapies Glucagon as an Antidote Hazardous chemical exposure Extracorporeal elimination in toxicology Gastric lavage GI Decontamination, gastrointestinal Magnesium Oxygen digibind Overdose favourites Paracetamol Acute paracetamol toxicity N-acetylcysteine Cocaine-associated chest pain Cocaine toxicity Amphetamine toxicity New recreational drugs, street drugs Toxic alcohols Ethanol intoxication Ethylene glycol toxicity Opioid overdose Benzylpiperazine Barbiturate overdose lithium Sodium valproate Sodium valproate overdose Carbamazepine toxicity Tricyclic antidepressant overdose Carbon monoxide poisoning theophyline Theophylline toxicity, methylxanthines Acute digoxin toxicity Chronic digoxin toxicty Beta blocker overdose Glucagon Therapy Calcium channel blocker toxicity Calcium, Digoxin Toxicty and Stone Heart Theory Sodium channel blocker toxicity Toxidromes Cholinergic syndrome Anticholinergic syndrome Organophosphate poisoning Paraquat poisoning Sympatholytic toxidrome Sympathomimetic toxidrome Sedative toxidrome Neuroleptic malignant syndrome Malignant hyperthermia Serotonin syndrome Withdrawal syndromes Drug withdrawal syndromes in ICU Alcohol withdrawal Chronic alcohol use Opioid withdrawal Anaesthetic and analgesic agents ketamine dexmedetomidine midazolam Morphine propofol advantages and disadvantages propofol infusion syndrome propofol thiopentone Anticoagulants and procoagulants Protamine Prothrombinex cleaxane, enoxaparin desmopressin, DDAVP alteplase, rTPA aprotinin low molecular weight heparin, LMWH, Tenecteplase, TNK-tPA Factor VIIa, seven, 7 heparin, unfractionated, UFH ticlodipine tranexamic acid, TXA warfarin Antiplatelet agents and NSAIDs NSAIDs Celecoxib COX II inhibitors Salicylate toxicity tirofiban clopidogrel aspirin dipyridamole Gastrointestinal pharmacopoeia octreotide omeprazole sucrulfate ranitidine terlipressin Antihypertensives and diuretics Enalalpril Captopril spironolactone Vasoactive drugs classification of vasoactive drugs dobutamine dopamine levosimendan versus dobutamine levosimendan methylene blue adrenaline milrinone noradrenaline Sodium nitroprusside phenylephrine vasopressin bosentan nitric oxide heliox prostacyclin, epoprostenol Antiarrhythmics Amiodarone Digoxin Lignocaine, Lidocaine Intralipid Adenosine Sotalol Antibiotics ceftriaxone rifampicin ciprofloxacin fluconazole cotrimoxazole lincomycin linezolid Benzylpenicillin, penicillin G gentamicin meropenem tazocin, piperacillin tazobactam imipenem vancomycin Miscellaneous substances of toxicological interest Polonium Activated protein C, drotrecogin alpha Ciguatera poisoning Marine envenoming, jellyfish, octopus, fish Mushroom toxicity, poisoning, fungi Plant toxicity, poisoning, herbal Scombroid poisoning, fish Snakebite envenoming Spider envenoming Tick paralysis, ixodid hard tick

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Pharmacology and toxicology

Toxicology and pharmacology broadly

Antidotes and forced enhanced clearance

Overdose favourites

Toxidromes

Withdrawal syndromes

Anaesthetic and analgesic agents

Anticoagulants and procoagulants

Antiplatelet agents and NSAIDs

Gastrointestinal pharmacopoeia

Antihypertensives and diuretics

Vasoactive drugs

Antiarrhythmics

Antibiotics

Miscellaneous substances of toxicological interest