Physiological effects of hyperoxia

This chapter is related to the aims of Section F10(ii) from the 2017 CICM Primary Syllabus, which expects the exam candidate to "explain the physiological effects of hyperoxia".  The college have asked about this in a very round-about way (Question 1 from the first paper of 2011) which was actually more about oxygen stores and preoxygenation. Though the chapter on the pharmacology of oxygen does cover this material to some substantial degree, a whole separate page dedicated to this topic seemed appropriate because it has its own syllabus entry (shared with hypoxia hypocapnia and hypercapnia), and also because the chapter on the pharmacology of oxygen takes the form of a disorganised rant, and for an exam answer some sort of an organised summary of hyperoxia needs to exist.

In terms of the aforementioned organisation, it's hard to structure information like this because the effects of increasing oxygen exposure are often dose-dependent and specific in each organ. Therefore, the best one can do is to organise the discussion by organ systems, and then by oxygen concentration. The latter can be separated into normobaric and hyperbaric, which seems like a useful distinction: some ill effects of oxygen can be seen when FiO2 is increased to 100% at normal atmospheric pressure, whereas others can only be seen in patients subjected to supranormal pressures. Anyway, in summary a table can be produced to neatly categorise these issues, which satisfies the author's unnatural lust for tables:

In terms of references, nobody covers normobaric hyperoxia better than Bruginaux et al (2018). Their article is comprehensive, free online and easy to read. There is also Jain (2017) for hyperbaric oxygen, which seems ideally suited for this topic, and is free from semanticscholar.org.